Published on January 7, 2022

Video Friday: Watch this quick review, “Vitamin D, Magnesium, and Vitamin B12 – A Cohort Study from Singapore”

Key Points

  • Vitamin D, along with other important co-nutrients (such as magnesium, vitamin B12, and many others), is essential for having an effective immune response against a pathogenic attack
  • One study showed that supplementation with vitamin D, magnesium, and vitamin B12 improved outcomes for hospitalized COVID-19 patients
  • Overall, 71% fewer patients required subsequent oxygen therapy or intensive care support when supplemented with the nutrient combination than those who were not supplemented

Amidst the ongoing COVID-19 pandemic, vitamin D deficiency itself is a major health concern that must be addressed in order to boost immune responses and improve COVID-19 outcomes among all populations. Much data has already been published showing a protective effect of vitamin D against severe COVID-19 outcomes and death. One such study reviewed in the video below shows how COVID-19 patients in a hospital in Singapore responded to supplementation with vitamin D, along with important co-nutrients magnesium and vitamin B12.

The video by Drbeen Medical Lectures provides a quick review of a study from Singapore by Tan et al., which found significantly reduced severe disease among patients admitted to a hospital with COVID-19 when provided supplementation of Vitamin D, Magnesium, and Vitamin B12 (DMB).

Watch the Video!

After watching the video, be sure to make note of the details below.

Vitamin D, Magnesium, and Vitamin B12 for COVID-19: Video Summary

  • The researchers hypothesized that patients given the nutrient combination would be less likely to require oxygen therapy, intensive care support, or both, compared to those who did not receive the nutrient combination
  • Out of 43 consecutive COVID-19 patients who were 50 years or older and did not require oxygen therapy upon admission, 17 received the vitamin D, magnesium, and vitamin B12 (DMB) combination, while 26 patients did not
  • Those receiving the DMB combination were given oral vitamin D (1000 IU/day), Magnesium (150 mg/day), and Vitamin B12 (500 mcg/day)
  • All patients enrolled were followed for 30 days or until hospital discharge to track any deterioration leading to oxygen therapy or the need for intensive care support

The Supplement Combination had a Significant Effect

Click to Enlarge & Print

  • 71% fewer patients required subsequent oxygen therapy or intensive care support in the DMB group than the non-DMB group, and the difference was significant
  • 3 out of the 17 patients (18%) in the DMB group required subsequent oxygen therapy or intensive care support, two of which required the therapy within 24 hours after their first supplement dose (meaning the supplements may not have had time to make a difference)
  • 16 of the 26 (62%) patients not receiving the DMB supplementation required subsequent oxygen therapy or intensive care support
  • Odds Ratio (OR) is a measurement that shows the strength of association between an intervention and an outcome; for this study, the outcome was the need for oxygen therapy or intensive care support, with the univariate analysis including whether or not the patient received the DMB combination, and multivariate analysis including adjustments for other influencing variables (including age and hypertension status)
  • Univariate analysis led to an OR of 0.13 for needing either or both oxygen therapy or intensive care support; this means receiving the DMB combination led to an 87% reduced risk of experiencing that outcome. The multivariate analysis led to an OR of 0.20, or an 80% reduced risk.

Are You Getting Enough Vitamin D, Magnesium, and Other Immune Boosting Nutrients?

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure, such as your vitamin D, omega-3s, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.


The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!