Breast Cancer Survival Linked to Vitamin D Level

Published on October 5, 2022

Study shows that women with the highest vitamin D level at breast cancer diagnosis had a better chance of survival

Vitamin D has known anticancer effects, and much research has been published over the last several decades showing a link between vitamin D levels and cancer risk. Depending on the type of cancer, vitamin D alone can potentially reduce the risk of cancer by about 25% to 80%.

In our last post, we summarized findings on breast cancer and vitamin D from an analysis published by GrassrootsHealth in 2018. This analysis that showed women with vitamin D levels at or above 60 ng/ml (150 nmol/L) had an 80% lower breast cancer risk compared to women with levels less than 20 ng/ml (50 nmol/L). In other previous posts we have discussed studies with similar results, such as an 83% lower breast cancer risk and a 2019 meta-analysis showing a 71% lower breast cancer risk.

Breast Cancer Survival Outcomes Associated with Vitamin D Level at Diagnosis

Research from Roswell Park Comprehensive Cancer Center and Kaiser Permanente was recently highlighted at the American Society of Clinical Oncology (ASCO) 2021 virtual annual meeting. The poster by Yao et al., Clinically sufficient vitamin D levels at breast cancer diagnosis and survival outcomes in a prospective cohort of 3,995 patients after a median follow-up of 10 years, summarized initial findings from Kaiser Permanente Northern California’s Pathways Study, involving women diagnosed with incident invasive breast cancer between 2006 and 2013, and their risk of death.

To analyze the data, vitamin D levels among the women at the time of breast cancer diagnosis were categorized as deficient (<20 ng/ml or <50 nmol/L), insufficient (20-30 ng/ml or 50-75 nmol/L), or sufficient (>30 ng/ml or >75 nmol/L).

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When compared to women whose vitamin D levels were deficient at the time of breast cancer diagnosis, women whose vitamin D levels were sufficient had a

27% lower risk of death overall (p=0.003)
21% lower risk of recurrence-free death (p=0.014)
18% lower risk of invasive disease-free death (p=0.026)

The study also looked at the most influential factors on the vitamin D dose response (or how the serum level responded to supplementation). Besides supplement amount, BMI and race/ethnicity had the most impact on vitamin D level, while genetic variants had a limited impact.

Black Women are at Much Higher Risk of Vitamin D Deficiency

In this study, black women had the lowest vitamin D levels, which the authors suggest is a major contributor to their poorer survival outcomes. Blacks overall have a 15-20 fold higher prevalence of severe vitamin D deficiency, which may account for a majority of their increased health and mortality risks. Blacks also have much higher mortality rates from diseases associated with vitamin D deficiency. In fact, an analysis by Ames et al. found that the risk of mortality for blacks is similar to the risk of mortality for whites when compared by vitamin D serum level! This indicates that correcting vitamin D deficiency and insufficiency among blacks could close the gap in mortality rates between blacks and whites.

In Conclusion

The authors state, “our findings support the use of daily vitamin D supplementation to maintain sufficient vitamin D levels after breast cancer diagnosis, particularly among Black women and patients diagnosed with a higher stage disease.”

Keep in mind that vitamin D levels of 60 ng/ml (150 nmol/L) or higher may provide even more benefit when it comes to breast cancer, as highlighted in several studies, including our paper titled Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥ 60 vs < 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort, which is among the top 10% of 2018 papers published in PLOS ONE for being cited in other research.

Breast cancer incidence has also been associated with levels of omega-3 fatty acids and magnesium intake, as well as the intake and status of other nutrients. Ensuring adequate intake of these nutrients, and measuring their levels, may be essential for those concerned with the prevention of breast cancer and many other chronic diseases.

Measure Your Level of Vitamin D and Other Important Nutrients

Having and maintaining healthy vitamin D levels and other nutrient levels can help improve your health now and for your future. Choose which to measure, such as your vitamin D, omega-3s, and essential minerals including magnesium and zinc, by creating your custom home test kit today. Take steps to improve the status of each of these measurements to benefit your overall health. You can also track your own intakes, symptoms and results to see what works best for YOU.

Enroll and test your levels today, learn what steps to take to improve your status of vitamin D (see below) and other nutrients and blood markers, and take action! By enrolling in the GrassrootsHealth projects, you are not only contributing valuable information to everyone, you are also gaining knowledge about how you could improve your own health through measuring and tracking your nutrient status, and educating yourself on how to improve it.

How Can You Use this Information for YOUR Health?

Having and maintaining healthy vitamin D and other nutrient levels can help improve your health now and for your future. Measuring is the only way to make sure you are getting enough!

STEP 1 Order your at-home blood spot test kit to measure vitamin D and other nutrients of concern to you, such as omega-3s, magnesium, essential and toxic elements (zinc, copper, selenium, lead, cadmium, mercury); include hsCRP as a marker of inflammation or HbA1c for blood sugar health

STEP 2 Answer the online questionnaire as part of the GrassrootsHealth study

STEP 3 Using our educational materials and tools (such as our dose calculators), assess your results to determine if you are in your desired target range or if actions should be taken to get there

STEP 4 After 3-6 months of implementing your changes, re-test to see if you have achieved your target level(s)

Enroll in D*action and Build Your Custom Test Kit!