What is the relationship between Omega-3 Index and Omega-6 to Omega-3 & AA to EPA Ratios?

Published on September 19, 2019

Omega-3 fatty acids are a healthy type of fat that comes in multiple forms. Long-chain omega-3s, primarily EPA and DHA which are found in fish and shellfish, have been linked to numerous health benefits. For the past two years, GrassrootsHealth has offered a home blood spot test that measures the amount of the EPA and DHA in red blood cell (RBC) membranes, which is called the Omega-3 Index. This measurement reflects long-term (about four months) intake of EPA and DHA from food and supplements. Evidence shows that an Omega-3 Index greater than 8% is optimal and less than 4% is deficient.

Additional testing using the same blood sample is available that can determine your ratio of pro-inflammatory omega-6 fatty acids, specifically LA and AA which are found in cooking oils, processed foods, and animal products, to anti-inflammatory omega-3s. An excess amount of omega-6s can lead to the development of chronic diseases. This test provides both your combined omega-6 to omega-3 ratio as well as your ratio of the primary pro/anti-inflammatory omegas (AA to EPA). Generally, a lower ratio is better for health; however, the optimal range for health has not been established. For the AA to EPA ratio, some experts consider the desirable range to be 2.5 to 11; others consider a range or 1.5 to 3 to be low risk, 3 to 6 to be moderate risk, 7-15 to be elevated risk, and above 15 to be high risk.

The primary way to improve both your Omega-3 Index and omega-6 to omega-3 ratio is by increasing intake of EPA and DHA through fatty fish intake and/or supplement use. Using the data you provided for the GrassrootsHealth study, we assessed the association between Omega-3 Index and omega-6 to omega-3 ratio and the AA to EPA ratio. As you can see on the charts below, there is a clear relationship between Omega-3 Index and the omega-6 to omega-3 and AA to EPA ratios. As Omega-3 Index increased (indicating higher EPA and DHA intake), the ratios decreased.

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Among those with an Omega-3 Index of 8% or higher, nearly all (99.7%) had an AA to EPA ratio lower than 11 and about half (49%) had a ratio of 3 or lower.

Are your Omega-3 levels in a healthy range?

Should you be taking steps to increase your omega-3 intake? Testing your Omega-3 Index levels along with your ratios, and taking daily steps to keep your Omega-3 Index at a target of at least 8%, and your vitamin D at a target level of 40-60 ng/ml (100-150 nmol/L), is important for many aspects of mental health. Find out your levels today! Log on to the shop (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created an online tracking system called myData-myAnswers. For each specific supplement, you can track what days you take it, how much, and many other details. This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!

How Can You Use this Information for YOUR Health?

Having and maintaining healthy vitamin D and other nutrient levels can help improve your health now and for your future. Measuring is the only way to make sure you are getting enough!

STEP 1 Order your at-home blood spot test kit to measure vitamin D and other nutrients of concern to you, such as omega-3s, magnesium, essential and toxic elements (zinc, copper, selenium, lead, cadmium, mercury); include hsCRP as a marker of inflammation or HbA1c for blood sugar health

STEP 2 Answer the online questionnaire as part of the GrassrootsHealth study

STEP 3 Using our educational materials and tools (such as our dose calculators), assess your results to determine if you are in your desired target range or if actions should be taken to get there

STEP 4 After 3-6 months of implementing your changes, re-test to see if you have achieved your target level(s)

Enroll in D*action and Build Your Custom Test Kit!