Published on May 14, 2019
Drs. Cedric Garland and Sharif Mohr, along with others on their research team, have published numerous ecological studies on the association between UVB irradiance and the incidence of type 1 diabetes and many different types of cancer. The key figure from these studies is a U-shaped “smiley” curve showing higher disease rates in the far northern and southern latitudes – locations that have lower UVB irradiance from the sun. Following are some of the findings from these studies.
UVB and Type 1 Diabetes Rates
Published in 2008, the chart below shows the incidence rates of type 1 diabetes in children aged less than 14 years for 51 regions in the world. Incidence rates were higher at higher latitudes and close to zero near the Equator (P<0.001). Dr. Garland and his research team found that higher UVB irradiance, adjusted for cloud cover, was associated with lower incidence rates (P<0.05).
UVB and Cancer Rates
Similar to type 1 diabetes, regions at higher latitudes have also been found to have higher rates of many cancers. The charts below show that higher latitude was associated with higher incidence rates of lung cancer, the most common cancer worldwide and the leading cause of cancer death among men and women in 111 countries (P<0.01). Additionally, higher UVB irradiance was associated with a lower risk of lung cancer in both men and women (P<0.01) after adjusting for cloud cover, cigarette use, and other risk factors.
A similar pattern has also been found for incidence rates of breast cancer, the second most common cancer in the world and the fifth leading cause of cancer death. The chart below shows breast cancer rates were higher in countries with higher latitude across 107 countries (P<0.0001). Also, higher UVB irradiance was associated with lower breast cancer risk (P=0.04) after adjusting for cloud cover and other factors such as alcohol and cigarette use, consumption of animal-based foods, and obesity.
Rates of colorectal cancer, the third most common cancer worldwide and the second leading cause of cancer death, are higher further from the Equator across 173 countries (P<0.0001). Additionally, higher UVB irradiance was associated with lower colorectal cancer risk (P<0.0001) after adjusting for cloud cover and other relevant factors.
Dr. Garland and his research team have also published similar results for ovarian cancer, endometrial cancer, renal cancer, bladder cancer, pancreatic cancer, brain cancer, leukemia, and multiple myeloma. The repeated pattern shown in these charts clearly show the association between UVB irradiance from the sun and rates of type 1 diabetes and many cancers. Increasing sun exposure at a population level may substantially decrease the rates of these diseases.
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