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Published on January 3, 2022

Supplementing with vitamin B6 with magnesium improved stress by an additional 24% compared to magnesium supplementation alone

Key Points

  • According to previous research, supplementing with magnesium has demonstrated a significant improvement in depression and anxiety symptoms
  • Vitamin B6 has also shown anti-stress benefits and it assists in the cellular uptake of magnesium
  • The study reviewed below showed a 24% greater improvement in stress in the magnesium with vitamin B6 group compared to the magnesium only group for those with severe or extremely severe stress

Magnesium is a mineral essential for many functions within the body. Magnesium is the second most prevalent cation within our cells, and is involved in 700-800 different enzyme systems, including protein synthesis, energy metabolism, bone development, muscle and nerve function, blood pressure regulation, and blood glucose control. Magnesium also plays a key role in the metabolism of other important minerals such as calcium and potassium, and is needed for vitamin D activation.

Other vitamins, including vitamin B6 (pyridoxine), are also known to work in conjunction with magnesium.

Magnesium, Vitamin B6, and Anxiety

A previous blog reviewed the results from a clinical trial assessing whether magnesium supplementation could improve depression and anxiety symptoms. Within two weeks, participants supplementing with magnesium demonstrated a significant improvement in depression and anxiety symptoms, whereas no improvement was seen in those without magnesium supplementation.

Another paper, published in PLoS ONE by Pouteau et al., looked at individuals with moderate to severe stress to see how treatment with magnesium or magnesium plus vitamin B6 affected perceived stress levels. Since vitamin B6 has also shown anti-stress benefits, and it assists in the cellular uptake of magnesium, this study compared the effects of magnesium alone versus magnesium combined with B6 on stress.

This study enrolled 268 adults with moderate to extremely severe stress who also presented with low levels of magnesium. Participants were randomized into two groups – one receiving either a combination of 470 mg magnesium with 5 mg vitamin B6 per day, or just 465 mg magnesium. Supplements were taken every day for eight weeks. Stress levels were assessed using a clinically validated questionnaire designed to measure levels of depression, anxiety, and stress over the previous week.

What were the findings of this study?

As illustrated in the chart below, both the magnesium only group and the magnesium plus B6 group experienced rapid and significant reductions in stress over the 8 week period; overall, the reduction was around 40%. However, there was a 24% greater improvement in stress in the magnesium with vitamin B6 group compared to the magnesium only group for those with severe or extremely severe stress.

Click to Enlarge & Print

This study is an example of how nutrients can work together to produce a greater effect on health than either nutrient alone.

How does your magnesium level compare to others?

Make sure you know your level of magnesium and are taking daily steps to keep it within range. Find out your levels today! Log on to the shop (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Shop Page

How can I track my magnesium level and intake?

To help you track your magnesium intake along with your resulting level, GrassrootsHealth has created an online tracking system called myData-myAnswers. You can track any of your supplemental and dietary nutrient intakes to see how they impact your levels and overall health. Check it out today!

What Does it Take YOU to Get Your D to 40 ng/ml (100 nmol/L)?

Did you know your health could be greatly affected by making sure you have a vitamin D level of at least 40 ng/ml (100 nmol/L)? Help us help you.

STEP 1 - Do you know what your vitamin D level is? If not, be sure to test today to find out.

STEP 2 – Determine your target level. Are you at your target level? Experts recommend a level of at least 40-60 ng/ml (100-150 nmol/L).

STEP 3 – Need to boost your level? Use the D*calculator to see how much vitamin D it may take to reach your target. Opt for the Loading Dose for a quicker boost.

STEP 4 – Optimize how your body absorbs and utilizes vitamin D with co-nutrients and these simple steps.

STEP 5 – Re-Test! This is an important step to make sure you have reached your target level, and to ensure you are not taking too much! Re-testing after 3-4 months is recommended.

STEP 6 – Adjust, Repeat…

Give your immune system the nutrients it needs to support a healthy you and protect yourself from unnecessary diseases, especially COVID-19.

NEWS ALERT

The first Randomized Controlled Trial on vitamin D and COVID-19 has shown a 96% lower risk of ICU admission for those receiving vitamin D (as 25(OH)D to quickly boost vitamin D blood levels) along with the standard treatment, compared to those receiving standard treatment alone.

These results support many previous observational studies showing a relationship between vitamin D levels and intake and COVID-19 severity.

Review the Latest Nutrient Research for COVID-19

GrassrootsHealth Nutrient Research Institute has launched the new Immune Boost project with the use of our myData-myAnswers nutrient health system that nearly 15,000 people are already using for their health. Specific markers that influence immune health are suggested for testing as part of this project including:

  • Vitamin D
  • Omega-3 Index
  • Essential elements magnesium, selenium, and zinc
  • hsCRP

Our goal is to demonstrate how one can use the Nutrient Research Model established by Dr. Robert Heaney to show the effect of vitamin D serum levels of at least 40 ng/ml (100 nmol/L) on risk reduction for all ethnicities in the population. Status and intake of other nutrients will also be analyzed for any type of relationship to immune status and symptom severity. Join the project today!

Please let us know if you're interested in helping sponsor this project.

CLICK HERE for updates and new information about the project.

Through GrassrootsHealth Nutrient Research Institute, you can also test your essential elements magnesium, copper, zinc and selenium, toxins such as lead, mercury and cadmium, as well as your omega-3 levels, inflammation levels and thyroid stimulating hormone (TSH) level. Find out your levels today! Log on to the test selection page (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Test Page

How can I track my nutrient intake and levels over time?

To help you track your supplement use and nutrient levels, GrassrootsHealth has created the Personal Health Nutrient Decision System called

For each specific supplement, you can track what days you take it, how much, and many other details.  This will help you know your true supplemental intake and what patterns of use work for you to reach and maintain optimum nutrient levels. Check it out today!