Published on September 13, 2019

Major Depressive Disorder (MDD) is a serious mental health issue that affects an estimated 7% of American adults every year, and it is a leading cause of disability world-wide. Previously, we have discussed the association between depression and magnesium, vitamin D, and omega-3s.

Omega-3 Effect on Depression Backed by Strongest Level of Evidence

The world’s largest review (called a meta-synthesis) of nutrient supplements and mental disorders published by Firth et al. examined 33 meta analyses of randomized controlled trials on dietary supplements and mental health. The analysis included data from 10,951 individuals with diagnoses such as depression, stress and anxiety, bipolar, personality disorder, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). The researchers looked at the potential benefits of specific nutrient supplements, including dosage, target symptoms, safety and tolerability, for each of the mood and mental disorders.

The strongest evidence from this review showed the effect of omega-3s (with an average dose of 1422 mg/day of EPA) on reducing symptoms of MDD, which produced benefits beyond those of taking antidepressants alone. The strongest effect was seen with omega-3 supplements that contained at least 50% EPA.

The chart below is a plot of the effect of omega-3 supplementation on depressive disorders as found in this analysis. The black diamonds represent studies with significant findings (where p<0.05) compared to placebo (9 out of the 12 studies included); circles represent studies with non-significant findings compared to placebo (3 out of 12 studies).

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Other findings from this review included the safety of all nutrients reviewed when taken as recommended, the absence of any serious adverse effect or contraindication between each nutrient and the psychiatric medications taken, a positive effect of omega-3 supplements on ADHD, a positive effect of folate on MDD and schizophrenia, and a positive effect of N-acetycysteine on mood and schizophrenia.

Are you or someone you love suffering from depression?

Could improving their omega-3 status help? Testing your vitamin D and Omega-3 Index levels and taking daily steps to keep your Omega-3 Index at a target of at least 8%, and your vitamin D at a target level of 40-60 ng/ml (100-150 nmol/L), is important for many aspects of mental health. Find out your levels today! Log on to the shop (click the link below) to get your tests and see for yourself if your levels can be improved.

Make sure you track your results before and after, about every 6 months!

Click Here to Access the Shop Page

How can I track my omega-3 intake and levels?

To help you track your nutrient intake and levels, GrassrootsHealth has created an online tracking system called myData-myAnswers. You can also track your health conditions and symptoms to see how your nutrient intake and status may impact your health and how you feel. Check it out today!

How Can You Use this Information for YOUR Health?

Having and maintaining healthy vitamin D and other nutrient levels can help improve your health now and for your future. Measuring is the only way to make sure you are getting enough!

STEP 1 Order your at-home blood spot test kit to measure vitamin D and other nutrients of concern to you, such as omega-3s, magnesium, essential and toxic elements (zinc, copper, selenium, lead, cadmium, mercury); include hsCRP as a marker of inflammation or HbA1c for blood sugar health

STEP 2 Answer the online questionnaire as part of the GrassrootsHealth study

STEP 3 Using our educational materials and tools (such as our dose calculators), assess your results to determine if you are in your desired target range or if actions should be taken to get there

STEP 4 After 3-6 months of implementing your changes, re-test to see if you have achieved your target level(s)

Enroll in D*action and Build Your Custom Test Kit!

Memorial Day Sale! Get 15% off home test kits with coupon code MAY15. Sale ends 5/31 at 11:59pm PST.